Nevertheless, Fauci’s case is more evidence that Paxlovid rebounds are a real concern.
#RAYBOUND ROUND TRIAL#
Assuming that you aren’t in the middle of a Paxlovid clinical trial yourself, it’s better for you to follow FDA guidance on such matters. He may have been taking the medication in more of a “clinical trial” setting where he could be closely watched and monitored in case something had gone wrong.
![raybound round raybound round](https://i.pinimg.com/736x/b0/74/12/b074126d4d1d00b80eb73970f30ee0ed.jpg)
You don’t know Fauci’s circumstances unless you happen to be Fauci. Just because you hear of people taking second courses of Paxlovid doesn’t mean that you should do it too. This would allow the virus to hang out until the Paxlovid is cleared from your body, sort of like a head of state trying to stay in office after an election tried to clear him out of there. So what appears to be a Paxlovid rebound could actually just a continuation of Covid-19 with some false negative tests thrown in the middle.Īdd to these, the possibility that the antiviral is not reaching all of the cells in your body that contain the virus. You may turn “negative” on antigen tests even though you are still infected and shedding the virus. Of course, an additional possibility is that the Covid-19 tests aren’t exactly super accurate at ruling out infection. Remember the SARS-CoV-2 can’t open doors since its spikes are way too small. This would have been much less likely had you remained isolated all the time. What seems like one stretch of Covid-19 actually is two separate infections. A third possibility is re-infection with the virus. It will allow the virus to survive potentially any number of Paxlovid courses. In such a case, resistance is not futile, for the virus that is. Another possibility is that the virus has developed resistance to the medication. Thus, once the five-day course is over, the remaining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in your body may start reproducing itself again. One is that the medication may not always suppress replication of virus long enough for your immune system and body to clear the virus. As I covered for Forbes about a month ago, there are several possible reasons. It may not even be clear why you are experiencing what appears to be a rebound. So before taking a second course of Paxlovid for possible rebound, you may want to wait for it, wait for it, wait for more scientific evidence that it will actually be warranted and useful. Getty Images) dpa/picture alliance via Getty Images (Photo by Fabian Sommer/picture alliance via. Pictured here are boxes of the medication Paxlovid. Indeed, the FDA Updates on Paxlovid for Health Care Providers website included the following as of May 4: “there is no evidence of benefit at this time for a longer course of treatment (e.g., 10 days rather than the 5 days recommended in the Provider Fact Sheet for Paxlovid) or repeating a treatment course of Paxlovid in patients with recurrent Covid-19 symptoms following completion of a treatment course.” A May 24, 2022, Centers for Disease Control and Prevention (CDC) Health Advisory indicated something similar: “There is currently no evidence that additional treatment for Covid-19 is needed for Covid-19 rebound.”
![raybound round raybound round](https://66.media.tumblr.com/2880faf89c6e4deca004395aa8f422bf/tumblr_nd0nuurZWu1t5m9xyo3_500.png)
![raybound round raybound round](https://i.pinimg.com/originals/47/10/8f/47108fd87a1ca74ee484a1b397cbc461.jpg)
Food and Drug Administration (FDA) technically did not cover a second course of Paxlovid for rebound Covid-19. Keep in mind that the initial Paxlovid emergency use authorization (EUA) from the U.S. So, does this mean that you should take a second course of Paxlovid if you are experiencing rebound Covid-19? Well, back on May 3,Riley Griffin, Madison Muller, and Robert Langreth writing for Bloomberg quoted Pfizer CEO Albert Bourla, DVM, PhD, with DVM standing for Doctor of Veterinary Medicine, as saying the following about a Paxlovid rebound, “then you give a second course, like you do with antibiotics, and that's it.” Umm, is that really it? Paxlovid is not the same as common antibiotics for bacteria.īefore you take medication advice from someone who’s not a medical doctor and who heads the company that makes the medication, talk to a medical doctor, a real medical doctor for humans. He added, “So I went back on Paxlovid and right now I am on my fourth day of a five-day course.” Fauci continued by saying, “fortunately I feel reasonably good but I’m not completely without symptoms.” Was the second course of Paxlovid then responsible for the improvement in his symptoms? Uh, possibly, maybe, perhaps.